Shaping inhibition: activity dependent structural plasticity of GABAergic synapses
نویسندگان
چکیده
منابع مشابه
Shaping inhibition: activity dependent structural plasticity of GABAergic synapses
Inhibitory transmission through the neurotransmitter γ-aminobutyric acid (GABA) shapes network activity in the mammalian cerebral cortex by filtering synaptic incoming information and dictating the activity of principal cells. The incredibly diverse population of cortical neurons that use GABA as neurotransmitter shows an equally diverse range of mechanisms that regulate changes in the strength...
متن کاملEditorial: Plasticity of GABAergic synapses
For long time, plasticity of brain circuits has been hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses have been assumed to be relatively invariant. Based on this view, inhibition should be exclusively modulated by the differential glutamatergic-driven activation of a highly diverse population of inhibitory interneurons displaying s...
متن کاملActivity-dependent structural plasticity.
Plasticity in the brain reaches far beyond a mere changing of synaptic strengths. Recent time-lapse imaging in the living brain reveals ongoing structural plasticity by forming or breaking of synapses, motile spines, and re-routing of axonal branches in the developing and adult brain. Some forms of structural plasticity do not follow Hebbian- or anti-Hebbian paradigms of plasticity but rather a...
متن کاملBidirectional activity-dependent plasticity at corticostriatal synapses.
Corticostriatal projections originate from the entire cerebral cortex and provide the major source of glutamatergic inputs to the basal ganglia. Despite the importance of corticostriatal connections in sensorimotor learning and cognitive functions, plasticity forms at these synapses remain strongly debated. Using a corticostriatal slice preserving the connections between the somatosensory corte...
متن کاملShort-term ionic plasticity at GABAergic synapses
Fast synaptic inhibition in the brain is mediated by the pre-synaptic release of the neurotransmitter γ-Aminobutyric acid (GABA)and the post-synaptic activation of GABA-sensitive ionotropic receptors. As with excitatory synapses, it is being increasinly appreciated that a variety of plastic processes occur at inhibitory synapses, which operate over a range of timescales. Here we examine a form ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2014
ISSN: 1662-5102
DOI: 10.3389/fncel.2014.00327